DOAJ Open Access 2021

A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients

Chirajyoti Deb Allan N. Salinas Tianyu Zheng Aurea Middleton Katelyn Kern +8 lainnya

Abstrak

Abstract Upon infection with SARS-CoV-2, the virus that causes COVID-19, most people will develop no or mild symptoms. However, a small percentage of the population will become severely ill, and some will succumb to death. The clinical severity of COVID-19 has a close connection to the dysregulation of the patient’s immune functions. We previously developed a simple, nanoparticle-enabled blood test that can determine the humoral immune status in animals. In this study, we applied this new test to analyze the immune function in relation to disease severity in COVID-19 patients. From the testing of 153 COVID-19 patient samples and 142 negative controls, we detected a drastic decrease of humoral immunity in COVID-19 patients who developed moderate to severe symptoms, but not in patients with no or mild symptoms. The new test may be potentially used to monitor the immunity change and predict the clinical risk of patients with COVID-19.

Topik & Kata Kunci

Medicine Science

Penulis (13)

Chirajyoti Deb

Allan N. Salinas

Tianyu Zheng

Aurea Middleton

Katelyn Kern

Daleen Penoyer

Rahul Borsadia

Charles Hunley

Bassam Abomoelak

Vijay Mehta

Laura Irastorza

Devendra I. Mehta

Qun Huo

Format Sitasi

APA MLA BibTeX

Deb, C., Salinas, A.N., Zheng, T., Middleton, A., Kern, K., Penoyer, D. et al. (2021). A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients. https://doi.org/10.1038/s41598-021-02863-2

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Informasi Jurnal

Tahun Terbit: 2021
Sumber Database: DOAJ
DOI: 10.1038/s41598-021-02863-2
Akses: Open Access ✓