DOAJ Open Access 2025

Microbiome dysbiosis and chemotherapy resistance in acute myeloid leukemia (AML)

Maojin Tian Hamed Soleimani Samarkhazan Seyed Shahabedin Alemohammad Milad Fakhraei Manesh Farzaneh Tavakoli +2 lainnya

Abstrak

Abstract AML often relapses due to chemotherapy resistance, increasingly linked to gut microbiome dysbiosis. Microbial drug modification, immune modulation, and metabolite-driven survival/epigenetic changes (e.g., SCFAs, kynurenine) promote resistance. Clinical data associate reduced diversity, loss of Faecalibacterium, and Enterococcus overgrowth with poorer outcomes. Microbiome interventions (FMT, probiotics, diet) show promise; priorities are standardizing methods and defining microbe–metabolite mechanisms to guide trials.

Topik & Kata Kunci

Microbial ecology

Penulis (7)

Maojin Tian

Hamed Soleimani Samarkhazan

Seyed Shahabedin Alemohammad

Milad Fakhraei Manesh

Farzaneh Tavakoli

Ali Shams

Amirhossein Zeynalabadi

Format Sitasi

APA MLA BibTeX

Tian, M., Samarkhazan, H.S., Alemohammad, S.S., Manesh, M.F., Tavakoli, F., Shams, A. et al. (2025). Microbiome dysbiosis and chemotherapy resistance in acute myeloid leukemia (AML). https://doi.org/10.1038/s41522-025-00891-8

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Lihat di Sumber doi.org/10.1038/s41522-025-00891-8

Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1038/s41522-025-00891-8
Akses: Open Access ✓