DOAJ Open Access 2025

Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells

Lili Xiao Jianju Liu Yi Chen Liang Xia Yumeng Jiang +9 lainnya

Abstrak

Abstract Noise-induced hearing loss (NIHL), a common sensory disorder, is traditionally thought to stem primarily from direct damage to sound-sensing hair cells (HCs). Here, we demonstrate that supporting cells (SCs), neighboring cells not previously implicated in NIHL pathogenesis, orchestrate hearing loss and HC degeneration through Gasdermin D (GSDMD) activation. Mechanistically, noise-induced oxidative stress in HCs triggers activation of epidermal growth factor receptor in SCs, leading to extracellular-regulated kinase phosphorylation and caspase-11-dependent cleavage of GSDMD, thereby establishing an HC-to-SC signaling cascade. Furthermore, GSDMD activation in SCs reciprocally exacerbates oxidative injury in HCs, creating a pathogenic positive feedback loop between the two cell types. Our findings uncover a central role for SCs in noise-induced hearing loss and identify GSDMD-mediated intercellular communication as a potential therapeutic target.

Topik & Kata Kunci

Science

Penulis (14)

Lili Xiao

Jianju Liu

Yi Chen

Liang Xia

Yumeng Jiang

Xiaoyan Chen

Tianjiao Zhou

Yan Sun

Wen Lu

Hui Wang

Jian Wang

Yanmei Feng

Zhen Zhang

Shankai Yin

Format Sitasi

APA MLA BibTeX

Xiao, L., Liu, J., Chen, Y., Xia, L., Jiang, Y., Chen, X. et al. (2025). Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells. https://doi.org/10.1038/s41467-025-66152-6

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1038/s41467-025-66152-6
Akses: Open Access ✓