A critical role of action-related functional networks in Gilles de la Tourette syndrome
Abstrak
Abstract Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants. We find that greater tic reduction is linked to higher connectivity of DBS sites (N = 37) with action-related functional resting-state networks, i.e., the cingulo-opercular (r = 0.62; p < 0.001) and somato-cognitive action networks (r = 0.47; p = 0.002). Regions of the cingulo-opercular network best match the optimal connectivity profiles of thalamic DBS. We replicate the significance of targeting cingulo-opercular and somato-cognitive action network connectivity in an independent DBS cohort (N = 10). Finally, we demonstrate that tic-inducing brain lesions (N = 22) exhibit similar connectivity to these networks. Collectively, these results suggest a critical role for these action-related networks in the pathophysiology and treatment of GTS.
Topik & Kata Kunci
Penulis (26)
Juan Carlos Baldermann
Jan Niklas Petry-Schmelzer
Thomas Schüller
Lin Mahfoud
Gregor A. Brandt
Till A. Dembek
Christina van der Linden
Joachim K. Krauss
Natalia Szejko
Kirsten R. Müller-Vahl
Christos Ganos
Bassam Al-Fatly
Petra Heiden
Domenico Servello
Tommaso Galbiati
Kara A. Johnson
Christopher R. Butson
Michael S. Okun
Pablo Andrade
Katharina Domschke
Gereon R. Fink
Michael D. Fox
Andreas Horn
Jens Kuhn
Veerle Visser-Vandewalle
Michael T. Barbe
Akses Cepat
- Tahun Terbit
- 2024
- Sumber Database
- DOAJ
- DOI
- 10.1038/s41467-024-55242-6
- Akses
- Open Access ✓