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DOAJ Open Access 2022

Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models

Hsueh-Fu Wu Wenxin Yu Kenyi Saito-Diaz Chia-Wei Huang Joseph Carey +4 lainnya
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Abstrak

Sympathetic neurons are affected in familial dysautonomia, a rare disease associated with a mutation in ELP1, but the mechanisms are not fully understood. Here the authors show, using neurons derived from participants with familial dysauotnomia, that spontaneous sympathetic neuron hyperactivity is observed and is associated with norepinephrine transporter deficits.

Topik & Kata Kunci

Science

Penulis (9)

H

Hsueh-Fu Wu

W

Wenxin Yu

K

Kenyi Saito-Diaz

C

Chia-Wei Huang

J

Joseph Carey

F

Frances Lefcort

G

Gerald W. Hart

H

Hong-Xiang Liu

N

Nadja Zeltner

Format Sitasi

APA MLA BibTeX
Wu, H., Yu, W., Saito-Diaz, K., Huang, C., Carey, J., Lefcort, F. et al. (2022). Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models. https://doi.org/10.1038/s41467-022-34811-7

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Informasi Jurnal
Tahun Terbit
2022
Sumber Database
DOAJ
DOI
10.1038/s41467-022-34811-7
Akses
Open Access ✓