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DOAJ Open Access 2023

Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis

Xi Li Yan Li Jintao Xiao Huiwen Wang Yan Guo +28 lainnya
Lihat Sumber DOI

Abstrak

The aetiology of primary biliary cholangitis (PBC) remains unclear. Here, the authors find that the numbers of DUOX2 + ACE2 + small cholangiocytes in human and mouse livers are inversely associated with disease severity, and present data indicating that they may be the target of polymeric immunoglobulin receptor (pIgR) -mediated humoral responses, suggesting that preservation of these cells and targeting anti-pIgR autoantibodies may be valuable strategies for therapeutic interventions in PBC.

Topik & Kata Kunci

Science

Penulis (33)

X

Xi Li

Y

Yan Li

J

Jintao Xiao

H

Huiwen Wang

Y

Yan Guo

X

Xiuru Mao

P

Pan Shi

Y

Yanliang Hou

X

Xiaoxun Zhang

N

Nan Zhao

M

Minghua Zheng

Y

Yonghong He

J

Jingjing Ding

Y

Ya Tan

M

Min Liao

L

Ling Li

Y

Ying Peng

X

Xuan Li

Q

Qiong Pan

Q

Qiaoling Xie

Q

Qiao Li

J

Jianwei Li

Y

Ying Li

Z

Zhe Chen

Y

Yongxiu Huang

D

David N. Assis

S

Shi-Ying Cai

J

James L. Boyer

X

Xuequan Huang

C

Can-E Tang

X

Xiaowei Liu

S

Shifang Peng

J

Jin Chai

Format Sitasi

APA MLA BibTeX
Li, X., Li, Y., Xiao, J., Wang, H., Guo, Y., Mao, X. et al. (2023). Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis. https://doi.org/10.1038/s41467-022-34606-w

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Lihat di Sumber doi.org/10.1038/s41467-022-34606-w
Informasi Jurnal
Tahun Terbit
2023
Sumber Database
DOAJ
DOI
10.1038/s41467-022-34606-w
Akses
Open Access ✓