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DOAJ Open Access 2021

HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway

Alison E. Smith Emanuela Ferraro Anton Safonov Cristina Bernado Morales Enrique J. Arenas Lahuerta +10 lainnya
Lihat Sumber DOI

Abstrak

Resistance to HER2 inhibition in HER2- amplified breast cancer is common in the metastatic setting and the underlying molecular mechanisms remain unknown. Here, the authors, perform genomic profiling of 733 HER2-amplified breast cancers and propose genetic activation of MAPK as a resistance mechanism.

Topik & Kata Kunci

Science

Penulis (15)

A

Alison E. Smith

E

Emanuela Ferraro

A

Anton Safonov

C

Cristina Bernado Morales

E

Enrique J. Arenas Lahuerta

Q

Qing Li

A

Amanda Kulick

D

Dara Ross

D

David B. Solit

E

Elisa de Stanchina

J

Jorge Reis-Filho

N

Neal Rosen

J

Joaquín Arribas

P

Pedram Razavi

S

Sarat Chandarlapaty

Format Sitasi

APA MLA BibTeX
Smith, A.E., Ferraro, E., Safonov, A., Morales, C.B., Lahuerta, E.J.A., Li, Q. et al. (2021). HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway. https://doi.org/10.1038/s41467-021-27093-y

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Informasi Jurnal
Tahun Terbit
2021
Sumber Database
DOAJ
DOI
10.1038/s41467-021-27093-y
Akses
Open Access ✓