DOAJ
Open Access
2021
A noncanonical AR addiction drives enzalutamide resistance in prostate cancer
Yundong He
Ting Wei
Zhenqing Ye
Jacob J. Orme
Dong Lin
+10 lainnya
Abstrak
Resistance to second generation anti-androgen therapies such as enzalutamide (ENZ) can emerge in prostate cancer patients. Here, the authors identify an ENZ-resistant mechanism driven by AR-dependent transcription of noncanonical targets that make resistant cells susceptible to dual inhibition of BET and CBP/p300 signaling.
Topik & Kata Kunci
Penulis (15)
Y
Yundong He
T
Ting Wei
Z
Zhenqing Ye
J
Jacob J. Orme
D
Dong Lin
H
Haoyue Sheng
L
Ladan Fazli
R
R. Jeffrey Karnes
R
Rafael Jimenez
L
Liguo Wang
L
Liewei Wang
M
Martin E. Gleave
Y
Yuzhuo Wang
L
Lei Shi
H
Haojie Huang
Akses Cepat
Informasi Jurnal
- Tahun Terbit
- 2021
- Sumber Database
- DOAJ
- DOI
- 10.1038/s41467-021-21860-7
- Akses
- Open Access ✓