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DOAJ Open Access 2020

Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection

Blair Armistead Pilar Herrero-Foncubierta Michelle Coleman Phoenicia Quach Christopher Whidbey +12 lainnya
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Abstrak

Granadaene, produced by Group B Streptococcus (GBS), is a long polyene lipid involved in cellular toxicity and hemolytic activity. Here, the authors synthesize and characterize granadaene-like compounds and show that a non-toxic analog diminishes GBS infection in mice when incorporated into a vaccine formulation.

Topik & Kata Kunci

Science

Penulis (17)

B

Blair Armistead

P

Pilar Herrero-Foncubierta

M

Michelle Coleman

P

Phoenicia Quach

C

Christopher Whidbey

J

Jose Justicia

R

Ruben Tapia

R

Raquel Casares

A

Alba Millán

A

Ali Haidour

J

Javier Rodriguez Granger

J

Jay Vornhagen

V

Verónica Santana-Ufret

S

Sean Merillat

K

Kristina Adams Waldorf

J

Juan Manuel Cuerva

L

Lakshmi Rajagopal

Format Sitasi

APA MLA BibTeX
Armistead, B., Herrero-Foncubierta, P., Coleman, M., Quach, P., Whidbey, C., Justicia, J. et al. (2020). Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection. https://doi.org/10.1038/s41467-020-15282-0

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Informasi Jurnal
Tahun Terbit
2020
Sumber Database
DOAJ
DOI
10.1038/s41467-020-15282-0
Akses
Open Access ✓