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DOAJ Open Access 2019

Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity

Xinyue Qi Fanlin Li Yi Wu Chen Cheng Ping Han +2 lainnya
Lihat Sumber DOI

Abstrak

Agonistic 4-1BB antibodies developed for cancer immunotherapy have suffered from either hepatotoxicity or insufficient anti-cancer activity. Here the authors determine the contribution of FcγR binding and agonistic strength to these outcomes, and engineer a 4-1BB antibody with potent anti-tumor effect and no liver toxicity in mice.

Topik & Kata Kunci

Science

Penulis (7)

X

Xinyue Qi

F

Fanlin Li

Y

Yi Wu

C

Chen Cheng

P

Ping Han

J

Jieyi Wang

X

Xuanming Yang

Format Sitasi

APA MLA BibTeX
Qi, X., Li, F., Wu, Y., Cheng, C., Han, P., Wang, J. et al. (2019). Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity. https://doi.org/10.1038/s41467-019-10088-1

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Informasi Jurnal
Tahun Terbit
2019
Sumber Database
DOAJ
DOI
10.1038/s41467-019-10088-1
Akses
Open Access ✓