DOAJ Open Access 2018

Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors

Fresia Pareja Alissa H. Brandes Thais Basili Pier Selenica Felipe C. Geyer +28 lainnya

Abstrak

Granular cell tumors (GCTs) are rare tumors that arise in multiple anatomical locations. Here, the authors investigate the genomics of GCTs, finding inactivating somatic mutations in ATP6AP1 or ATP6AP2 in 72% of the 82 GCTs analyzed. In vitro manipulation of these genes recapitulated GCT phenotypes in cellular models.

Topik & Kata Kunci

Science

Penulis (33)

Fresia Pareja

Alissa H. Brandes

Thais Basili

Pier Selenica

Felipe C. Geyer

Dan Fan

Arnaud Da Cruz Paula

Rahul Kumar

David N. Brown

Rodrigo Gularte-Mérida

Barbara Alemar

Rui Bi

Raymond S. Lim

Ino de Bruijn

Sho Fujisawa

Rui Gardner

Elvin Feng

Anqi Li

Edaise M. da Silva

John R. Lozada

Pedro Blecua

Leona Cohen-Gould

Achim A. Jungbluth

Emad A. Rakha

Ian O. Ellis

Maria I. A. Edelweiss

Juan Palazzo

Larry Norton

Travis Hollmann

Marcia Edelweiss

Brian P. Rubin

Britta Weigelt

Jorge S. Reis-Filho

Format Sitasi

APA MLA BibTeX

Pareja, F., Brandes, A.H., Basili, T., Selenica, P., Geyer, F.C., Fan, D. et al. (2018). Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors. https://doi.org/10.1038/s41467-018-05886-y

Akses Cepat

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Informasi Jurnal

Tahun Terbit: 2018
Sumber Database: DOAJ
DOI: 10.1038/s41467-018-05886-y
Akses: Open Access ✓