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DOAJ Open Access 2018

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

Jason X. Cheng Li Chen Yuan Li Adam Cloe Ming Yue +9 lainnya
Lihat Sumber DOI

Abstrak

Resistance to chemotherapy is a serious issue that can be influenced by RNA epigenetics and chromatin structure. Here, the authors show in leukaemia cells that RNA 5-methylcytosine (RNA:m5C) and RNA:m5C methyltransferases (RCMTs) mediate chromatin structures that can modulate 5-Azacitidine response and resistance.

Topik & Kata Kunci

Science

Penulis (14)

J

Jason X. Cheng

L

Li Chen

Y

Yuan Li

A

Adam Cloe

M

Ming Yue

J

Jiangbo Wei

K

Kenneth A. Watanabe

J

Jamile M. Shammo

J

John Anastasi

Q

Qingxi J. Shen

R

Richard A. Larson

C

Chuan He

M

Michelle M. Le Beau

J

James W. Vardiman

Format Sitasi

APA MLA BibTeX
Cheng, J.X., Chen, L., Li, Y., Cloe, A., Yue, M., Wei, J. et al. (2018). RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. https://doi.org/10.1038/s41467-018-03513-4

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Lihat di Sumber doi.org/10.1038/s41467-018-03513-4
Informasi Jurnal
Tahun Terbit
2018
Sumber Database
DOAJ
DOI
10.1038/s41467-018-03513-4
Akses
Open Access ✓