DOAJ Open Access 2025

Glutamine: fructose-6-phosphate amidotransferase (GFAT) in the pathology of diseases: a review

Caiting Yang Fengyu Chu Xiaoli Chen Fanqi Meng Yinhao Li +9 lainnya

Abstrak

Abstract Glutamine: fructose-6-phosphate amidotransferase (GFAT), a conserved enzyme across prokaryotic and eukaryotic species, is the first and rate-limiting step in the hexosamine biosynthetic pathway (HBP), diverting 2–5% of fructose-6-phosphate derived from glucose toward the synthesis of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a key substrate for the glycosylation of proteins and lipids. While substantial progress has been made in elucidating the basic biochemical properties and regulatory mechanisms of GFAT, its functional impact on pathological processes remains incompletely understood. Emerging evidence implicates GFAT in a spectrum of human diseases, including cancer, diabetes, cardiovascular disorders, and neurodegenerative conditions such as Alzheimer’s disease. This review aims to provide a comprehensive synthesis of current insights into GFAT’s role in disease etiology, with the goal of informing future research and therapeutic strategies targeting this essential metabolic regulator.

Topik & Kata Kunci

Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology

Penulis (14)

Caiting Yang

Fengyu Chu

Xiaoli Chen

Fanqi Meng

Yinhao Li

Jingwen Chen

Chaoyang Sun

Yahui Shang

Ruibin Guo

Jianming Wang

Changxin Wu

Huiping Duan

Miaomiao Shao

Wei Yuan

Format Sitasi

APA MLA BibTeX

Yang, C., Chu, F., Chen, X., Meng, F., Li, Y., Chen, J. et al. (2025). Glutamine: fructose-6-phosphate amidotransferase (GFAT) in the pathology of diseases: a review. https://doi.org/10.1038/s41420-025-02898-8

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1038/s41420-025-02898-8
Akses: Open Access ✓