DOAJ Open Access 2021

LncRNA coordinates Hippo and mTORC1 pathway activation in cancer

Shugeng Zhang Shuhang Liang Dehai Wu Hongrui Guo Kun Ma +1 lainnya

Abstrak

Abstract The Hippo and mammalian target of rapamycin complex 1 (mTORC1) pathways are the two predominant pathways that regulate tumour growth and metastasis. Therefore, we explored the potential crosstalk between these two functionally relevant pathways to coordinate their tumour growth-control functions. We found that a Hippo pathway-related long noncoding RNA, HPR, directly interacts with Raptor, an essential component of mTORC1, to upregulate mTORC1 activation by impairing the phosphorylation of Raptor by AMPK. Knockdown or knockout of HPR in breast cancer and cholangiocarcinoma cells led to a reduction in tumour growth. Compared with HPR WT cells, HPR-overexpressing cells exhibited nuclear accumulation of YAP1, and significantly blocked the downregulation of mTORC1 signalling induced by energy stress. Thus, our study reveals a direct link between the Hippo and mTORC1 pathways in the control of tumour growth.

Topik & Kata Kunci

Cytology

Penulis (6)

Shugeng Zhang

Shuhang Liang

Dehai Wu

Hongrui Guo

Kun Ma

Lianxin Liu

Format Sitasi

APA MLA BibTeX

Zhang, S., Liang, S., Wu, D., Guo, H., Ma, K., Liu, L. (2021). LncRNA coordinates Hippo and mTORC1 pathway activation in cancer. https://doi.org/10.1038/s41419-021-04112-w

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Informasi Jurnal

Tahun Terbit: 2021
Sumber Database: DOAJ
DOI: 10.1038/s41419-021-04112-w
Akses: Open Access ✓