DOAJ Open Access 2021

Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes

Nadine Hosny El Said Francesco Della Valle Peng Liu Andreu Paytuví-Gallart Sabir Adroub +2 lainnya

Abstrak

Abstract PRC2-mediated epigenetic function involves the interaction with long non-coding RNAs (lncRNAs). Although the identity of some of these RNAs has been elucidated in the context of developmental programs, their counterparts in postmitotic adult tissue homeostasis remain uncharacterized. To this aim, we used terminally differentiated postmitotic skeletal muscle cells in which oxidative stress induces the dynamic activation of PRC2-Ezh1 through Embryonic Ectoderm Develpment (EED) shuttling to the nucleus. We identify lncRNA Malat-1 as a necessary partner for PRC2-Ezh1-dependent response to oxidative stress. We show that in this pathway, PRC2-EZH1 dynamic assembly, and in turn stress induced skeletal muscle targeted genes repression, depends specifically on Malat-1. Our study reports about PRC2–RNA interactions in the physiological context of adaptive oxidative stress response and identifies the first lncRNA involved in PRC2-Ezh1 function.

Topik & Kata Kunci

Cytology

Penulis (7)

Nadine Hosny El Said

Francesco Della Valle

Peng Liu

Andreu Paytuví-Gallart

Sabir Adroub

Juliette Gimenez

Valerio Orlando

Format Sitasi

APA MLA BibTeX

Said, N.H.E., Valle, F.D., Liu, P., Paytuví-Gallart, A., Adroub, S., Gimenez, J. et al. (2021). Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes. https://doi.org/10.1038/s41419-021-04082-z

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Informasi Jurnal

Tahun Terbit: 2021
Sumber Database: DOAJ
DOI: 10.1038/s41419-021-04082-z
Akses: Open Access ✓