DOAJ Open Access 2020

The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer

Pei Xu Haibo Xiao Qi Yang Rui Hu Lianyong Jiang +6 lainnya

Abstrak

Lung cancer: Targeting a vicious circle Therapies targeting a molecular feedback loop involved in tumor growth may prove valuable for treating non-small-cell lung cancer. Fangbao Ding, Jianbing Huang, and co-workers at Shanghai Jiao Tong University in Shanghai, China, have shown how an enzyme called USP21 promotes cancer cell proliferation and tumor growth in non-small-cell lung cancer. The team took cancerous and non-cancerous lung tissue samples from 42 patients, and analyzed the expression and behavior of USP21. The enzyme was highly expressed in cancerous tissues, where it stabilized a known gene with the potential to cause cancer called YY1. This gene also regulated the expression of a particular RNA molecule, which in turn worked to increase levels of USP21. This cyclical process encouraged the proliferation, migration and invasion of non-small-cell lung cancer cells, and may provide a future therapeutic target.

Topik & Kata Kunci

Medicine Biochemistry

Penulis (11)

Pei Xu

Haibo Xiao

Qi Yang

Rui Hu

Lianyong Jiang

Rui Bi

Xueyan Jiang

Lei Wang

Ju Mei

Fangbao Ding

Jianbing Huang

Format Sitasi

APA MLA BibTeX

Xu, P., Xiao, H., Yang, Q., Hu, R., Jiang, L., Bi, R. et al. (2020). The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer. https://doi.org/10.1038/s12276-019-0356-6

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Informasi Jurnal

Tahun Terbit: 2020
Sumber Database: DOAJ
DOI: 10.1038/s12276-019-0356-6
Akses: Open Access ✓