DOAJ Open Access 2016

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Patrizia Cammareri Aidan M. Rose David F. Vincent Jun Wang Ai Nagano +24 lainnya

Abstrak

Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous squamous cell carcinomas.

Topik & Kata Kunci

Science

Penulis (29)

Patrizia Cammareri

Aidan M. Rose

David F. Vincent

Jun Wang

Ai Nagano

Silvana Libertini

Rachel A. Ridgway

Dimitris Athineos

Philip J. Coates

Angela McHugh

Celine Pourreyron

Jasbani H. S. Dayal

Jonas Larsson

Simone Weidlich

Lindsay C. Spender

Gopal P. Sapkota

Karin J. Purdie

Charlotte M. Proby

Catherine A. Harwood

Irene M. Leigh

Hans Clevers

Nick Barker

Stefan Karlsson

Catrin Pritchard

Richard Marais

Claude Chelala

Andrew P. South

Owen J. Sansom

Gareth J. Inman

Format Sitasi

APA MLA BibTeX

Cammareri, P., Rose, A.M., Vincent, D.F., Wang, J., Nagano, A., Libertini, S. et al. (2016). Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. https://doi.org/10.1038/ncomms12493

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Informasi Jurnal

Tahun Terbit: 2016
Sumber Database: DOAJ
DOI: 10.1038/ncomms12493
Akses: Open Access ✓