DOAJ Open Access 2017

Bortezomib alters sour taste sensitivity in mice

Akihiro Ohishi Kentaro Nishida Karin Miyamoto Mizuka Imai Ryoko Nakanishi +3 lainnya

Abstrak

Chemotherapy-induced taste disorder is one of the critical issues in cancer therapy. Bortezomib, a proteasome inhibitor, is a key agent in multiple myeloma therapy, but it induces a taste disorder. In this study, we investigated the characteristics of bortezomib-induced taste disorder and the underlying mechanism in mice. Among the five basic tastes, the sour taste sensitivity of mice was significantly increased by bortezomib administration. In bortezomib-administered mice, protein expression of PKD2L1 was increased. The increased sour taste sensitivity induced by bortezomib returned to the control level on cessation of its administration. These results suggest that an increase in protein expression of PKD2L1 enhances the sour taste sensitivity in bortezomib-administered mice, and this alteration is reversed on cessation of its administration. Keywords: Taste disorder, Bortezomib, Sour taste, Chemotherapy, Adverse effect

Topik & Kata Kunci

Toxicology. Poisons

Penulis (8)

Akihiro Ohishi

Kentaro Nishida

Karin Miyamoto

Mizuka Imai

Ryoko Nakanishi

Kyoko Kobayashi

Akiko Hayashi

Kazuki Nagasawa

Format Sitasi

APA MLA BibTeX

Ohishi, A., Nishida, K., Miyamoto, K., Imai, M., Nakanishi, R., Kobayashi, K. et al. (2017). Bortezomib alters sour taste sensitivity in mice. https://doi.org/10.1016/j.toxrep.2017.03.003

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Informasi Jurnal

Tahun Terbit: 2017
Sumber Database: DOAJ
DOI: 10.1016/j.toxrep.2017.03.003
Akses: Open Access ✓