DOAJ Open Access 2022

Human induced pluripotent stem cells generated from a 45-years-old male donor of type 2 diabetes mellitus with APOE-epsilon3/epsilon3 alleles

Shuxing Cao Ruiyun Guo Jinyu Zhang Xin Liu Zijing Zhou +2 lainnya

Abstrak

Apolipoprotein E (APOE) gene encodes three protein isoforms (APOEε-22/ε-33/ε-44), which governs the transportation and metabolism of lipoproteins differently. While abnormalities in lipid and lipoprotein metabolism have been identified as risk factors for type 2 diabetes mellitus (T2DM). APOE gene polymorphisms might be correlated with increased risk of T2DM. Therefore, we presented an iPSC line harboring an APOE-ε3/ε3 alleles, a male donor suffering from T2DM combined with Hypertension. The derived iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes. Collectively, the present study provides a useful resource to reveal the associated mechanism of APOE isoform and T2DM.

Topik & Kata Kunci

Biology (General)

Penulis (7)

Shuxing Cao

Ruiyun Guo

Jinyu Zhang

Xin Liu

Zijing Zhou

Yongzhou Song

Jun Ma

Format Sitasi

APA MLA BibTeX

Cao, S., Guo, R., Zhang, J., Liu, X., Zhou, Z., Song, Y. et al. (2022). Human induced pluripotent stem cells generated from a 45-years-old male donor of type 2 diabetes mellitus with APOE-epsilon3/epsilon3 alleles. https://doi.org/10.1016/j.scr.2022.102840

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.1016/j.scr.2022.102840
Akses: Open Access ✓