DOAJ Open Access 2023

Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report

Kohei Okada Rie Sakakibara Takayuki Honda Takahiro Mitsumura Sho Shibata +5 lainnya

Abstrak

A 74-year-old man was referred to our hospital with an abnormal chest shadow. Computed tomography (CT) revealed a mass in the left upper lobe and interstitial pneumonia (IP). The patient underwent CT-guided needle biopsy and was diagnosed as lung adenocarcinoma with cT2aN1M1a Stage IVA (PUL). The patient was administered 6 cycles of CBDCA + nab-paclitaxel as first-line, 3 cycles of atezolizumab as second-line, and 8 cycles of S-1 as third-line treatment but finally showed tumor progression. Because comprehensive genome profiling test revealed KRAS G12C mutation, sotorasib was initiated as fourth-line treatment and showed tumor regression without exacerbation of pre-existing IP.

Topik & Kata Kunci

Diseases of the respiratory system

Penulis (10)

Kohei Okada

Rie Sakakibara

Takayuki Honda

Takahiro Mitsumura

Sho Shibata

Tsuyoshi Shirai

Tsukasa Okamoto

Haruhiko Furusawa

Tomoya Tateishi

Yasunari Miyazaki

Format Sitasi

APA MLA BibTeX

Okada, K., Sakakibara, R., Honda, T., Mitsumura, T., Shibata, S., Shirai, T. et al. (2023). Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report. https://doi.org/10.1016/j.rmcr.2023.101929

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.1016/j.rmcr.2023.101929
Akses: Open Access ✓