DOAJ Open Access 2025

Estrogen metabolites and hydrogen peroxide - Missing elements in the pathophysiology and possible treatment of treatment-resistant depression?

Zofia Winczewska Agnieszka Mechlińska Piotr Radziwiłłowicz Lucyna Konieczna Joanna Drzeżdżon +5 lainnya

Abstrak

The pathogenesis of depression is complex and heterogeneous, and the management of this disease remains unsatisfactory, so mechanisms and therapeutic strategies are constantly being sought. This study aimed to determine the potential role of estrogen metabolites in the pathogenesis of treatment-resistant depression (TRD) based on the determination of concentrations of estrogens and their metabolites and hydrogen peroxide (H202) in the biological material of patients with TRD.In this study, we observed for the first time an association between unbalanced estrogen metabolism and elevated H202 levels in TRD patients. Reduced concentrations of 2-methoxyestradiol (2-ME2), 17α-estradiol (α-E2) and 17β-estradiol (β-E2) may be due to abnormal estrogen metabolism toward neurotoxic semiquinones and quinones which are a potential as yet undescribed mechanism responsible for generating oxidative stress (OS) in TRD.

Topik & Kata Kunci

Medicine (General) Biology (General)

Penulis (10)

Zofia Winczewska

Agnieszka Mechlińska

Piotr Radziwiłłowicz

Lucyna Konieczna

Joanna Drzeżdżon

Dagmara Jacewicz

Mariusz Wiglusz

Tomasz Bączek

Wiesław Jerzy Cubała

Magdalena Górska-Ponikowska

Format Sitasi

APA MLA BibTeX

Winczewska, Z., Mechlińska, A., Radziwiłłowicz, P., Konieczna, L., Drzeżdżon, J., Jacewicz, D. et al. (2025). Estrogen metabolites and hydrogen peroxide - Missing elements in the pathophysiology and possible treatment of treatment-resistant depression?. https://doi.org/10.1016/j.redox.2025.103547

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1016/j.redox.2025.103547
Akses: Open Access ✓