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DOAJ Open Access 2020

Redox regulation of tumor suppressor PTEN in cell signaling

Ying Zhang Jiyoung Park Seong-Jeong Han Sung Yeul Yang Hyun Joong Yoon +3 lainnya
Lihat Sumber DOI

Abstrak

Phosphatase and tensin homologs deleted on chromosome 10 (PTEN) is a potent tumor suppressor and often dysregulated in cancers. Cellular PTEN activity is restrained by the oxidation of active-site cysteine by reactive oxygen species (ROS). Recovery of its enzymatic activity predominantly depends on the availability of cellular thioredoxin (Trx) and peroxiredoxins (Prx), both are important players in cell signaling. Trx and Prx undergo redox-dependent conformational changes through the oxidation of cysteine residues at their active sites. Their dynamics are essential for protein functionality and regulation. In this review, we summarized the recent advances regarding the redox regulation of PTEN, with a specific focus on our current state-of-the-art understanding of the redox regulation of PTEN. We also proposed a tight association of the redox regulation of PTEN with Trx dimerization and Prx hyperoxidation, providing guidance for the identification of novel therapeutic targets.

Topik & Kata Kunci

Medicine (General) Biology (General)

Penulis (8)

Y

Ying Zhang

J

Jiyoung Park

S

Seong-Jeong Han

S

Sung Yeul Yang

H

Hyun Joong Yoon

I

Iha Park

H

Hyun Ae Woo

S

Seung-Rock Lee

Format Sitasi

APA MLA BibTeX
Zhang, Y., Park, J., Han, S., Yang, S.Y., Yoon, H.J., Park, I. et al. (2020). Redox regulation of tumor suppressor PTEN in cell signaling. https://doi.org/10.1016/j.redox.2020.101553

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Informasi Jurnal
Tahun Terbit
2020
Sumber Database
DOAJ
DOI
10.1016/j.redox.2020.101553
Akses
Open Access ✓