DOAJ Open Access 2019

Raster-scan optoacoustic angiography of blood vessel development in colon cancer models

Anna Orlova Marina Sirotkina Ekaterina Smolina Vadim Elagin Andrey Kovalchuk +2 lainnya

Abstrak

Raster-scan optoacoustic angiography at 532 nm wavelength with 50 μm lateral resolution at 2 mm diagnostic depth was used for quantitative characterization of neoangiogenesis in colon cancer models. Two tumor models of human colon adenocarcinoma (HT-29) and murine colon carcinoma (CT26) different in their histology and vascularization were compared. Tumors of both origins showed an inhomogeneous distribution of areas with high and low vascularization. Rapidly growing CT26 tumor demonstrated a higher rate of vessel growth from the periphery to the center. Peculiarities of the vascularity of tumor models revealed by optoacoustic imaging were confirmed by fluorescent microscopy with FITC-dextran and morphological analysis. The obtained results may be important for the investigation of tumor development and for improvement of colon cancer treatment strategies. Keywords: Optoacoustic imaging, Colon cancer models, Tumor vessel development

Topik & Kata Kunci

Physics Acoustics. Sound Optics. Light

Penulis (7)

Anna Orlova

Marina Sirotkina

Ekaterina Smolina

Vadim Elagin

Andrey Kovalchuk

Ilya Turchin

Pavel Subochev

Format Sitasi

APA MLA BibTeX

Orlova, A., Sirotkina, M., Smolina, E., Elagin, V., Kovalchuk, A., Turchin, I. et al. (2019). Raster-scan optoacoustic angiography of blood vessel development in colon cancer models. https://doi.org/10.1016/j.pacs.2018.11.005

Akses Cepat

PDF tidak tersedia langsung

Cek di sumber asli →

Lihat di Sumber doi.org/10.1016/j.pacs.2018.11.005

Informasi Jurnal

Tahun Terbit: 2019
Sumber Database: DOAJ
DOI: 10.1016/j.pacs.2018.11.005
Akses: Open Access ✓