DOAJ Open Access 2019

Engineering and Design of Chimeric Antigen Receptors

Sonia Guedan Hugo Calderon Avery D. Posey, Jr. Marcela V. Maus

Abstrak

T cells engineered with chimeric antigen receptors (CARs) have emerged as a potent new class of therapeutics for cancer, based on their remarkable potency in blood cancers. Since the first clinical reports of their efficacy emerged 7 years ago, investigators have focused on the mechanisms and properties that make CARs effective or toxic, and their effects on T cell biology. Novel CAR designs coupled with improvements in gene transfer technology, incorporating advances in gene editing, have the potential to increase access to engineered cell therapies, as well as improve their potency in solid tumors. Keywords: CAR T cells, immunotherapy, chimeric antigen receptors, cancer

Topik & Kata Kunci

Genetics Cytology

Penulis (4)

Sonia Guedan

Hugo Calderon

Avery D. Posey, Jr.

Marcela V. Maus

Format Sitasi

APA MLA BibTeX

Guedan, S., Calderon, H., Jr., A.D.P., Maus, M.V. (2019). Engineering and Design of Chimeric Antigen Receptors. https://doi.org/10.1016/j.omtm.2018.12.009

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Informasi Jurnal

Tahun Terbit: 2019
Sumber Database: DOAJ
DOI: 10.1016/j.omtm.2018.12.009
Akses: Open Access ✓