The correlation between the CT texture features of gastric cancer in arterial phase and the expression of HER-2 and Ki-67

Objective: To investigate the correlation between the characteristic parameters of CT texture in arterial phase of gastric cancer and the expression of HER-2 and Ki-67. Methods: A total of 72 patients with gastric cancer in the First People's Hospital of Kashgar (October 2014 to October 2023) were collected, including 51 males and 21 females, with an average age of 58.9 years. According to the expression of HER-2 and Ki-67, the patients were divided into negative and positive expression group. The CT texture parameters of tumor arterial phase were measured by 3D Slicer-Radiomics CT texture analysis software. Results: Arterial phase CT texture parameters including P90, entropy, quartile, maximum, mean deviation, absolute deviation of gross error, root mean, uniformity and variance were associated with HER-2 expression (P < 0.05). There was no significant correlation between HER-2 expression level and P10, energy, kurtosis, mean, median, minimum, range, skewness and total energy (P > 0.05). Ki-67 expression level was not correlated with the CT texture parameters in arterial phase (P > 0.05). The ROC curve analysis and the results of AUC showed that the diagnostic efficiency of entropy was the highest (AUC = 0.71, P = 0.006). Conclusion: CT arterial phase texture parameters could predict the expression of HER-2 protein in gastric cancer, but could not predict the expression of Ki-67 protein.