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DOAJ Open Access 2021

Exploring the Complex Role of Coagulation Factor VIII in Chronic Liver DiseaseSummary

Tirthadipa Pradhan-Sundd Shweta Gudapati Tomasz W. Kaminski Margaret V. Ragni
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Abstrak

Chronic liver disease is one of the leading causes of death in the United States. Coagulopathy is often a sequela of chronic liver disease, however, the role and regulation of coagulation components in chronic liver injury remain poorly understood. Clinical and experimental evidence indicate that misexpression of the procoagulant factor VIII (FVIII) is associated with chronic liver disease. Nevertheless, the molecular mechanism of FVIII-induced chronic liver injury progression remains unknown. This review provides evidence supporting a pathologic role for FVIII in the development of chronic liver disease using both experimental and clinical models.

Topik & Kata Kunci

Diseases of the digestive system. Gastroenterology

Penulis (4)

T

Tirthadipa Pradhan-Sundd

S

Shweta Gudapati

T

Tomasz W. Kaminski

M

Margaret V. Ragni

Format Sitasi

APA MLA BibTeX
Pradhan-Sundd, T., Gudapati, S., Kaminski, T.W., Ragni, M.V. (2021). Exploring the Complex Role of Coagulation Factor VIII in Chronic Liver DiseaseSummary. https://doi.org/10.1016/j.jcmgh.2021.02.014

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Lihat di Sumber doi.org/10.1016/j.jcmgh.2021.02.014
Informasi Jurnal
Tahun Terbit
2021
Sumber Database
DOAJ
DOI
10.1016/j.jcmgh.2021.02.014
Akses
Open Access ✓