DOAJ Open Access 2025

Astrocyte-to-neuron interaction via NF-κB/C3/C3aR mediates chronic post-thoracotomy pain by modulating neuronal GluR1 in spinal dorsal horn

Wanying Mou Ning Yu Fengrun Sun Huan Cui Hanyu Zhang +6 lainnya

Abstrak

Summary: Chronic post-thoracotomy pain (CPTP) is a debilitating postoperative complication associated with persistent hypersensitivity and neuroinflammatory changes. Here, we identify an astrocyte-neuron signaling cascade mediated by NF-κB/C3/C3aR that drives excitatory synaptic remodeling in the spinal dorsal horn during CPTP. Using a rat model, we show that the activation of astroglial NF-κB promotes C3 synthesis, which interacts with neuronal C3aR to enhance GluR1 expression and synaptic localization, thereby facilitating pain hypersensitivity. The pharmacological inhibition of NF-κB or knockdown of astroglial C3 or neuronal C3aR markedly attenuated mechanical and cold allodynia, accompanied by reduced GluR1 expression. These findings define a mechanistic link between glial NF-κB activation, complement signaling, and neuronal excitatory transmission, highlighting the NF-κB/C3/C3aR pathway as a potential therapeutic target for chronic postoperative pain.

Topik & Kata Kunci

Science

Penulis (11)

Wanying Mou

Ning Yu

Fengrun Sun

Huan Cui

Hanyu Zhang

Yan Cao

Sixuan Jin

Chao Ma

Afang Zhu

Lulu Ma

Yuguang Huang

Format Sitasi

APA MLA BibTeX

Mou, W., Yu, N., Sun, F., Cui, H., Zhang, H., Cao, Y. et al. (2025). Astrocyte-to-neuron interaction via NF-κB/C3/C3aR mediates chronic post-thoracotomy pain by modulating neuronal GluR1 in spinal dorsal horn. https://doi.org/10.1016/j.isci.2025.113917

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1016/j.isci.2025.113917
Akses: Open Access ✓