Adolescents’ pain-related ontogeny shares a neural basis with adults’ chronic pain in basothalamo-cortical organization
Abstrak
Summary: During late adolescence, the brain undergoes ontogenic organization altering subcortical-cortical circuitry. This includes regions implicated in pain chronicity, and thus alterations in the adolescent ontogenic organization could predispose to pain chronicity in adulthood - however, evidence is lacking. Using resting-state functional magnetic resonance imaging from a large European longitudinal adolescent cohort and an adult cohort with and without chronic pain, we examined links between painful symptoms and brain connectivity. During late adolescence, thalamo-, caudate-, and red nucleus-cortical connectivity were positively and subthalamo-cortical connectivity negatively associated with painful symptoms. Thalamo-cortical connectivity, but also subthalamo-cortical connectivity, was increased in adults with chronic pain compared to healthy controls. Our results indicate a shared basis in basothalamo-cortical circuitries between adolescent painful symptomatology and adult pain chronicity, with the subthalamic pathway being differentially involved, potentially due to a hyperconnected thalamo-cortical pathway in chronic pain and ontogeny-driven organization. This can inform neuromodulation-based prevention and early intervention.
Topik & Kata Kunci
Penulis (28)
Nils Jannik Heukamp
Tobias Banaschewski
Arun L.W. Bokde
Sylvane Desrivières
Antoine Grigis
Hugh Garavan
Penny Gowland
Andreas Heinz
Mina Kandić
Rüdiger Brühl
Jean-Luc Martinot
Marie-Laure Paillère Martinot
Eric Artiges
Dimitri Papadopoulos Orfanos
Herve Lemaitre
Martin Löffler
Luise Poustka
Sarah Hohmann
Sabina Millenet
Juliane H. Fröhner
Michael N. Smolka
Katrin Usai
Nilakshi Vaidya
Henrik Walter
Robert Whelan
Gunter Schumann
Herta Flor
Frauke Nees
Akses Cepat
- Tahun Terbit
- 2024
- Sumber Database
- DOAJ
- DOI
- 10.1016/j.isci.2024.108954
- Akses
- Open Access ✓