Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes
Abstrak
Summary: High-protein diets are promoted for individuals with type 2 diabetes (T2D). However, effects of dietary protein interventions on (gut-derived) metabolites in T2D remains understudied. We therefore performed a multi-center, randomized-controlled, isocaloric protein intervention with 151 participants following either 12-week high-protein (HP; 30Energy %, N = 78) vs. low-protein (LP; 10 Energy%, N = 73) diet. Primary objectives were dietary effects on glycemic control which were determined via glycemic excursions, continuous glucose monitors and HbA1c. Secondary objectives were impact of diet on gut microbiota composition and -derived metabolites which were determined by shotgun-metagenomics and mass spectrometry. Analyses were performed using delta changes adjusting for center, baseline, and kidney function when appropriate.This study found that a short-term 12-week isocaloric protein modulation does not affect glycemic parameters or weight in metformin-treated T2D. However, the HP diet slightly worsened kidney function, increased alpha-diversity, and production of potentially harmful microbiota-dependent metabolites, which may affect host metabolism upon prolonged exposure.
Topik & Kata Kunci
Penulis (27)
Ilias Attaye
Pierre Bel Lassen
Solia Adriouch
Emilie Steinbach
Rafael Patiño-Navarrete
Mark Davids
Rohia Alili
Flavien Jacques
Sara Benzeguir
Eugeni Belda
Ina Nemet
James T. Anderson
Laure Alexandre-Heymann
Arno Greyling
Etienne Larger
Stanley L. Hazen
Sophie L. van Oppenraaij
Valentina Tremaroli
Katharina Beck
Per-Olof Bergh
Fredrik Bäckhed
Suzan P.M. ten Brincke
Hilde Herrema
Albert K. Groen
Sara-Joan Pinto-Sietsma
Karine Clément
Max Nieuwdorp
Akses Cepat
- Tahun Terbit
- 2023
- Sumber Database
- DOAJ
- DOI
- 10.1016/j.isci.2023.107471
- Akses
- Open Access ✓