DOAJ Open Access 2023

Development of vessel mimicking microfluidic device for studying mechano-response of endothelial cells

Pei-Yu Chu Han-Yun Hsieh Pei-Shan Chung Pai-Wen Wang Ming-Chung Wu +3 lainnya

Abstrak

Summary: The objective of this study is to develop a device to mimic a microfluidic system of human arterial blood vessels. The device combines fluid shear stress (FSS) and cyclic stretch (CS), which are resulting from blood flow and blood pressure, respectively. The device can reveal real-time observation of dynamic morphological change of cells in different flow fields (continuous flow, reciprocating flow and pulsatile flow) and stretch. We observe the effects of FSS and CS on endothelial cells (ECs), including ECs align their cytoskeleton proteins with the fluid flow direction and paxillin redistribution to the cell periphery or the end of stress fibers. Thus, understanding the morphological and functional changes of endothelial cells on physical stimuli can help us to prevent and improve the treatment of cardiovascular diseases.

Topik & Kata Kunci

Science

Penulis (8)

Pei-Yu Chu

Han-Yun Hsieh

Pei-Shan Chung

Pai-Wen Wang

Ming-Chung Wu

Yin-Quan Chen

Jean-Cheng Kuo

Yu-Jui Fan

Format Sitasi

APA MLA BibTeX

Chu, P., Hsieh, H., Chung, P., Wang, P., Wu, M., Chen, Y. et al. (2023). Development of vessel mimicking microfluidic device for studying mechano-response of endothelial cells. https://doi.org/10.1016/j.isci.2023.106927

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.1016/j.isci.2023.106927
Akses: Open Access ✓