DOAJ Open Access 2021

Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease

Cuiyan Xin Jiahui Lei Qian Wang Yixia Yin Xiaoqian Yang +5 lainnya

Abstrak

Summary: Chronic kidney disease (CKD) is associated with substantial morbidity and mortality. We developed a mouse model that mimics human CKD with inflammation, extracellular matrix deposition, tubulointerstitial fibrosis, increased proteinuria, and associated reduction in glomerular filtration rate over time. Using this model, we show that genetic deficiency of SMOC2 or therapeutic silencing of SMOC2 with small interfering RNAs (siRNAs) after disease onset significantly ameliorates inflammation, fibrosis, and kidney function loss. Mechanistically, we found that SMOC2 promotes fibroblast to myofibroblast differentiation by activation of diverse cellular signaling pathways including MAPKs, Smad, and Akt. Thus, targeting SMOC2 therapeutically offers an approach to prevent fibrosis progression and CKD after injury.

Topik & Kata Kunci

Science

Penulis (10)

Cuiyan Xin

Jiahui Lei

Qian Wang

Yixia Yin

Xiaoqian Yang

Jose Alberto Moran Guerrero

Venkata Sabbisetti

Xiaoming Sun

Vishal S. Vaidya

Joseph V. Bonventre

Format Sitasi

APA MLA BibTeX

Xin, C., Lei, J., Wang, Q., Yin, Y., Yang, X., Guerrero, J.A.M. et al. (2021). Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease. https://doi.org/10.1016/j.isci.2021.103193

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Informasi Jurnal

Tahun Terbit: 2021
Sumber Database: DOAJ
DOI: 10.1016/j.isci.2021.103193
Akses: Open Access ✓