Full-Arch Implant Treatment In A Hajdu-Cheney Syndrome Patient.

Introduction: In this case, full-arch implant prosthetic rehabilitation was performed on a Hajdu-Cheney syndrome (HCS) patient. The treatment outcomes were systematically evaluated, including implant stability, occlusal reconstruction functionality, aesthetic restoration, and postoperative quality of life. Case description: This case details the dental implant treatment of a 23-year-old female presenting with progressive tooth mobility and loss. CBCT imaging demonstrated maxillofacial skeletal dysplasia, aberrant trabecular bone architecture, and severe alveolar bone resorption. The patient exhibited maxillofacial and limb deformities, osteoporosis and acro-osteolysis. Given the diagnostic challenges posed by the disease's rarity and complexity, we conducted genetic sequencing on the patient and ultimately confirmed the diagnosis of HCS. Finally, we performed a dental implant procedure on the patient. The maxilla received four implants (Dentium SuperLine®), with six implants placed in the mandible. Final restoration comprised mandibular fixed prostheses and maxillary Locator overdentures. Discussion: Hajdu-Cheney syndrome represents a rare hereditary metabolic osteopathy. Since Hajdu's initial documentation of cases in 1948 and Cheney's identification of familial patterns in 1965, approximately 80 confirmed cases have been reported globally. Notably, Dokou et al. (2005) achieved successful implant placement in an HCS patient without postoperative complications, establishing the preliminary feasibility of such interventions. Conclusion/clinical significance: This case represents the first documented complete oral rehabilitation using eight dental implants in an HCS patient, with all implants demonstrating clinical success and no major complications observed during the follow-up period. The therapeutic protocol provides valuable insights for developing evidence-based implant strategies in this special patient population.