Adenomatoid tumor of the adrenal Gland: A case report and review of literature

Adenomatoid tumor is a rare benign neoplasm that arises from mesothelial cells. It is commonly found in the genital tract, and the adrenal gland is an is an extremely rare location for adenomatoid tumor. Herein we report a rare case of adrenal adenomatoid tumor in an 83-year-old man with a history of lung non-small cell carcinoma. CT scan of the abdomen revealed a 2.2 x 1.5 cm nodular lesion in the left adrenal gland. Subsequent biopsy of the adrenal lesion revealed extensive tubular-like and vascular like spaces, which were lined with flat or cuboidal cells. The tumor cells showed minimal cytologic atypia with low proliferative activity. Immunohistochemically, the tumor cells were positive for pancytokeratin, calretinin, WT-1, D2-40, and CK7; and negative for TTF-1, SOX10, HMB45, SF1, ERG, and CD31. The overall features are consistent with adenomatoid tumor. We also reviewed adrenal adenomatoid tumors that have been reported in the English literature and identified the morphological and immunohistochemical characteristics that can be used to distinguish adenomatoid tumor from its mimickers in the adrenal gland.