DOAJ Open Access 2026

A case of glomerulonephritis with dominant C3 with organized deposits complicated by non-tuberculous mycobacteria

Masanori Sudo Chihiro Sakurazawa Yuichi Sakamaki Masato Habuka Asa Ogawa +7 lainnya

Abstrak

We report a case of membranoproliferative glomerulonephritis (MPGN) with dominant C3 and uniquely organized deposits complicated by pulmonary non-tuberculous mycobacterial (NTM) infection. A 64-year-old man developed persistent urinary abnormalities following treatment with Mycobacterium malmoense. A renal biopsy revealed MPGN with characteristic fibrous organized deposits and strong complement C3c and fibrinogen positivity, but IgG, IgA, IgM, and C1q negativity. Immunosuppressive therapy was not administered. The patient’s renal function gradually declined, but subsequently stabilized with prolonged antibiotic therapy. This case highlights the importance of considering infection-related glomerulonephritis with C3-dominant organized deposits, particularly in the absence of any immunoglobulin involvement, as well as the need to distinguish this entity from primary C3 glomerulopathy.

Topik & Kata Kunci

Pathology

Penulis (12)

Masanori Sudo

Chihiro Sakurazawa

Yuichi Sakamaki

Masato Habuka

Asa Ogawa

Yumi Ito

Naofumi Imai

Sayuri Takamura

Satoshi Ito

Akira Shimizu

Shin Goto

Suguru Yamamoto

Format Sitasi

APA MLA BibTeX

Sudo, M., Sakurazawa, C., Sakamaki, Y., Habuka, M., Ogawa, A., Ito, Y. et al. (2026). A case of glomerulonephritis with dominant C3 with organized deposits complicated by non-tuberculous mycobacteria. https://doi.org/10.1016/j.hpr.2026.300828

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Informasi Jurnal

Tahun Terbit: 2026
Sumber Database: DOAJ
DOI: 10.1016/j.hpr.2026.300828
Akses: Open Access ✓