A mechanistic overview on green assisted formulation of nanocomposites and their multifunctional role in biomedical applications

The importance of nanocomposites constantly attains attention because of their unique properties all across the fields especially in medical perspectives. The study of green-synthesized nanocomposites has grown to be extremely fascinating in the field of research. Nanocomposites are more promising than mono-metallic nanoparticles because they exhibit synergistic effects. This review encapsulates the current development in the formulation of plant-mediated nanocomposites by using several plant species and the impact of secondary metabolites on their biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, and in vivo actions, characterized by varying sizes, shapes, and biochemical nature. This process is advantageous to conventional physical and chemical procedures. New studies have been conducted to determine the biomedical efficacy of nanocomposites against various diseases. Unfortunately, there has been inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized nanocomposites in therapeutic interventions not only enhances healing processes but also augments the host's immune defenses against infections. This review highlights the phytosynthesis of nanocomposites and their various biomedical applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, and other applications, as well as their toxicity. This review also explores the mechanistic action of nanocomposites to achieve their designated tasks. Biogenic nanocomposites for multimodal imaging have the potential to exchange the conventional methods and materials in biomedical research. Well-designed nanocomposites have the potential to be utilized in various biomedical fields as innovative theranostic agents with the subsequent objective of efficiently diagnosing and treating a variety of human disorders.