DOAJ Open Access 2024

GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal

Jinlong Zhang Jie Yan Shuyue Li Qianqian Chen Jiang Lin +6 lainnya

Abstrak

Methamphetamine is a potent and highly addictive neurotoxic psychostimulant that triggers a spectrum of adverse emotional responses during withdrawal. G-protein coupled receptor 55 (GPR55), a novel endocannabinoid receptor, is closely associated with mood regulation. Herein, we developed a murine model of methamphetamine-induced anxiety- and depressive-like behavior during abstinence which showed a decreased GPR55 expression in the hippocampus. Activation of GPR55 mitigated these behavioral symptoms, concomitantly ameliorating impairments in hippocampal neurogenesis and reducing neuroinflammation. These findings underscore the pivotal role of GPR55 in mediating the neuropsychological consequences of methamphetamine withdrawal, potentially via mechanisms involving the modulation of hippocampal neurogenesis and inflammation.

Topik & Kata Kunci

Science (General) Social sciences (General)

Penulis (11)

Jinlong Zhang

Jie Yan

Shuyue Li

Qianqian Chen

Jiang Lin

Yilin Peng

Yuhang Liu

Binbin Wang

Xinrong Wei

Chen Sun

Shuliang Niu

Format Sitasi

APA MLA BibTeX

Zhang, J., Yan, J., Li, S., Chen, Q., Lin, J., Peng, Y. et al. (2024). GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal. https://doi.org/10.1016/j.heliyon.2024.e30462

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Informasi Jurnal

Tahun Terbit: 2024
Sumber Database: DOAJ
DOI: 10.1016/j.heliyon.2024.e30462
Akses: Open Access ✓