DOAJ Open Access 2025

Direct C(sp3)-H functionalization with thiosulfonates via photoredox catalysis

Linfeng Liu Yujian Pang Canliang Ma Daiqing Zhou Wenjie Zhang +7 lainnya

Abstrak

While C(sp3)-S bonds exist in many biologically active compounds, the direct catalytic C(sp3)-H thiolation remains elusive. Herein, we report a convenient and green C(sp3)-H thiolation approach mediated by using tetrabutylammonium decatungstate (TBADT) as a hydrogen atom transfer (HAT) photocatalyst. A wide range of C(sp3)-H bond-containing etheric, allylic, alkyl, ketonic, amidic substrates and sulfonyl-based SOMOphiles participated in the reaction, producing thioethers with high efficiency. The present protocol features green characteristics, such as being free of harmful oxidants and additives; step-economic; redox-neutral; and amenable to scale-up assisted by continuous-flow technology.

Topik & Kata Kunci

Chemical technology Biochemistry

Penulis (12)

Linfeng Liu

Yujian Pang

Canliang Ma

Daiqing Zhou

Wenjie Zhang

Jin Huang

Jie Sun

Jiangkai Qiu

Yihuan Liu

Lei Shen

Zhenjiang Li

Kai Guo

Format Sitasi

APA MLA BibTeX

Liu, L., Pang, Y., Ma, C., Zhou, D., Zhang, W., Huang, J. et al. (2025). Direct C(sp3)-H functionalization with thiosulfonates via photoredox catalysis. https://doi.org/10.1016/j.gresc.2024.05.003

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1016/j.gresc.2024.05.003
Akses: Open Access ✓