DOAJ Open Access 2022

Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

Amoolya Kandettu Divya Adiga Vasudha Devi Padmanaban S. Suresh Sanjiban Chakrabarty +2 lainnya

Abstrak

Ovarian cancer (OC) is one of the most common and fatal types of gynecological cancer. OC is usually detected at the advanced stages of the disease, making it highly lethal. miRNAs are single-stranded, small non-coding RNAs with an approximate size ranging around 22 nt. Interestingly, a considerable proportion of miRNAs are organized in clusters with miRNA genes placed adjacent to one another, getting transcribed together to result in miRNA clusters (MCs). MCs comprise two or more miRNAs that follow the same orientation during transcription. Abnormal expression of the miRNA cluster has been identified as one of the key drivers in OC. MC exists both as tumor-suppressive and oncogenic clusters and has a significant role in OC pathogenesis by facilitating cancer cells to acquire various hallmarks. The present review summarizes the regulation and biological function of MCs in OC. The review also highlights the utility of abnormally expressed MCs in the clinical management of OC.

Topik & Kata Kunci

Medicine (General) Genetics

Penulis (7)

Amoolya Kandettu

Divya Adiga

Vasudha Devi

Padmanaban S. Suresh

Sanjiban Chakrabarty

Raghu Radhakrishnan

Shama Prasada Kabekkodu

Format Sitasi

APA MLA BibTeX

Kandettu, A., Adiga, D., Devi, V., Suresh, P.S., Chakrabarty, S., Radhakrishnan, R. et al. (2022). Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine. https://doi.org/10.1016/j.gendis.2021.12.026

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.1016/j.gendis.2021.12.026
Akses: Open Access ✓