DOAJ Open Access 2022

Amidoxime functionalized chitosan for uranium sequestration in vivo

Zhiheng Li Siyi Wang Yipu Dong Xiaoyao Miao Bingkun Xiao +3 lainnya

Abstrak

Amidoxime functionalized chitosan (AC) was recommended as a chelator for uranium sequestration in vivo in this study, and the structure-activity relationship was also explored. Compared with ZnNa3-DTPA, which was a commercial uranium mobilization drug, AC exhibited excellent biocompatibility and uranium removal efficiency, whether by injection or orally, which could reduce the amounts of uranium deposited in kidneys and femurs by up to 43.6% and 32.3%. In particular, ACs still possessed the ability to mobilize uranium in vivo even if administration was delayed for 72 h.

Topik & Kata Kunci

Environmental pollution Environmental sciences

Penulis (8)

Zhiheng Li

Siyi Wang

Yipu Dong

Xiaoyao Miao

Bingkun Xiao

Jianyun Yang

Jianfeng Zhao

Rongqing Huang

Format Sitasi

APA MLA BibTeX

Li, Z., Wang, S., Dong, Y., Miao, X., Xiao, B., Yang, J. et al. (2022). Amidoxime functionalized chitosan for uranium sequestration in vivo. https://doi.org/10.1016/j.ecoenv.2022.113636

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.1016/j.ecoenv.2022.113636
Akses: Open Access ✓