DOAJ Open Access 2026

Cancer burden and risk factors among women with HIV: a multi-regional study from the D:A:D and RESPOND cohort collaborationsResearch in context

Win Min Han Bastian Neesgaard Michael Knappik Matthias Cavassini Irene A. Abela +260 lainnya

Abstrak

Summary: Background: Data on cancer incidence and associated risk factors among women with HIV are limited. We investigated cancer burden among women with HIV. Methods: We included all women ≥18 years from the two large multicentre observational cohort collaborations (D:A:D and RESPOND). The primary outcomes were incidence of all cancers, HPV-related and common individual cancers including breast cancer, lung cancer, and non-Hodgkin lymphoma (NHL) from 2006 to 2021. Baseline was defined as the latest date of entry into local cohort enrolment and 1st January 2006 for D:A:D and 1st January 2012 for RESPOND. Participants were followed from baseline until the date of first cancer, final follow-up or administrative censoring—whichever occurred first. We assessed risk factors using multivariable Poisson regression by applying robust standard errors and determined a population attributable fraction (PAF) for key risk factors for cancers. Findings: Among 17,512 women included, median age at baseline was 39.5 years (interquartile range, IQR 32.5–46.0). Over 141,404 person-years (PYS) and a median 9.2 (5.5–10.1) years of follow-up, 832 women were diagnosed with any cancer; incidence rate 5.9 (95% CI 5.5–6.4)/1000 PYS, 163 HPV-related cancers (1.1 [1.0–1.3]/1000 PYS), 150 breast cancers (1.1 [0.9–1.2]/1000 PYS), 94 lung cancers (0.7 [0.5–0.8]/1000 PYS) and 72 NHL (0.5 [0.4–0.6]/1000 PYS). Older age (≥45 vs. <45 years), Southern Europe (vs. Western Europe) and smoking were associated with an increased risk of overall cancers. Lower pre-ART nadir CD4, time-updated CD4, and a prior AIDS diagnosis were associated with lung- and HPV-related cancer. In PAF analysis, smoking and HIV-related factors such as lower current CD4, nadir CD4 and HIV viremia significantly contributed to cancer risk. Interpretation: Our findings suggest that women with HIV older than 45 years, past or current immunosuppressed or current smokers could be candidates for intensified cancer screening and prevention. Funding: The Highly Active Antiretroviral Therapy Oversight Committee, The CHU St Pierre Brussels HIV Cohort, The Austrian HIV Cohort Study, The Australian HIV Observational Database, The AIDS Therapy Evaluation in the Netherlands national observational HIV cohort, The Brighton HIV Cohort, The National Croatian HIV Cohort, The EuroSIDA cohort, The Frankfurt HIV Cohort Study, The Georgian National AIDS Health Information System, The Nice HIV Cohort, The Isabel Foundation, The Modena HIV Cohort, The PISCIS Cohort Study, The Swiss HIV Cohort Study, The Swedish InfCare HIV Cohort, The Royal Free HIV Cohort Study, The San Raffaele Scientific Institute, The University Hospital Bonn HIV Cohort, The University of Cologne HIV Cohort, Merck Life Sciences, ViiV Healthcare, and Gilead Sciences.

Topik & Kata Kunci

Medicine (General)

Penulis (265)

Win Min Han

Bastian Neesgaard

Michael Knappik

Matthias Cavassini

Irene A. Abela

Alisa Timiryasova

Lauren Greenberg

Charlotte Martin

Cristina Mussini

Ferdinand Wit

Caroline Sabin

Antonella Castagna

Akaki Abutidze

Wafaa El-Sadr

Fabrice Bonnet

Mario Sarcletti

Christina Carlander

Anna Hachfeld

Nina Weis

Vani Vannappagari

Felipe P. Rogatto

Lital A. Young

Sean R. Hosein

Lene Ryom

Kathy Petoumenos

W. El-Sadr

G. Calvo

F. Bonnet

F. Dabis

O. Kirk

A. Mocroft

M. Law

A. d'Arminio Monforte

L. Morfeldt

C. Pradier

P. Reiss

R. Weber

S. De Wit

A. Lind-Thomsen

R. Salbøl Brandt

M. Hillebreght

S. Zaheri

F. Wit

A. Scherrer

F. Schöni-Affolter

M. Rickenbach

A. Tavelli

I. Fanti

O. Leleux

J. Mourali

F. Le Marec

E. Boerg

E. Thulin

A. Sundström

G. Bartsch

G. Thompsen

C. Necsoi

M. Delforge

E. Fontas

C. Caissotti

K. Dollet

S. Mateu

F. Torres

K. Petoumenos

A. Blance

R. Huang

R. Puhr

K. Grønborg Laut

D. Kristensen

C. Sabin

A. Phillips

D. Kamara

C. Smith

C. Hatleberg

L. Ryom

A. Lind-Thomsen

R. Brandt

D. Raben

C. Matthews

A. Bojesen

A. Grevsen

J. Lundgren

B. Powderly

N. Shortman

C. Moecklinghoff

G. Reilly

X. Franquet

O. Kirk

P. Reiss

C. Smit

M. Ross

C. Fux

P. Morlat

E. Fontas

D. Kamara

J. Lundgren

C. Hatleberg

R. Weber

P. Morlat

C. Pradier

P. Reiss

N. Friis-Møller

J. Kowalska

J. Lundgren

C. Hatleberg

M. Law

A. d'Arminio Monforte

F. Dabis

F. Bonnet

P. Reiss

D. Kamara

J. Bohlius

M. Bower

G. Fätkenheuer

A. Grulich

J. Lundgren

A. Sjøl

P. Meidahl

J. Iversen

F. Wit

M. van der Valk

M. Hillebregt

K. Petoumenos

M. Law

W. Min Han

R. Zangerle

H. Appoyer

J. Vera

A. Clarke

B. Broster

L. Barbour

D. Carney

L. Greenland

R. Coughlan

S. De Wit

M. Delforge

J. Begovac

J. Kowalska

C. Stephan

M. Bucht

N. Chkhartishvili

O. Chokoshvili

A. d'Arminio Monforte

A. Rodano

A. Tavelli

I. Fanti

C. Mussini

V. Borghi

M. Menozzi

A. Cervo

C. Pradier

E. Fontas

K. Dollet

C. Caissotti

J. Casabona

J. Miro

F. Burns

C. Smith

F. Lampe

C. Chaloner

A. Castagna

A. Lazzarin

R. Lolatto

A. Sönnerborg

C. Carlander

P. Nowal

J. Vesterbacka

D. Carrick

K. Stigsäter

L. Mattson

H. Günthard

K. Kusejko

J. Wasmuth

J. Rockstroh

J. Vehreschild

G. Fätkenheuer

M. Scherer

G. Sauer

N. Schulze

L. Ryom

R. Campo

H. Garges

J. Lundgren

F. Bognar

J. Rooney

V. Vannappagari

G. Wandeler

L. Young

N. Dedes

M. Dunbar

C. Necsoi

L. Peters

D. Raben

A. Volny-Anne

L. Greenberg

N. Jaschinski

A. Timiryasova

L. Bansi-Matharu

E. Tusch

W. Bannister

A. Roen

D. Byonanebye

O. Fursa

A. Pelchen-Matthews

J. Reekie

V. Svedhem-Johansson

K. Grabmeier-Pfistershammer

J. Hoy

M. Bloch

D. Braun

A. Calmy

G. Schüttfort

M. Youle

S. Zona

A. Antinori

N. Bolokadze

J. Llibre

C. Schwarze-Zander

J. Hutchinson

C. Duvivier

G. Dragovic

R. Radoi

C. Oprea

M. Vasylyev

R. Matulionyte

V. Mulabdic

G. Marchetti

E. Kuzovatova

N. Coppola

I. Aho

S. Martini

H. Bucher

A. Harxhi

T. Wæhre

A. Pharris

A. Vassilenko

J. Bogner

A. Maagaard

E. Jablonowska

D. Elbirt

G. Marrone

C. Leen

C. Wyen

L. Dahlerup Rasmussen

C. Hatleberg

M. Kundro

E. Dixon Williams

J. Gallant

C. Cohen

A. Marongiu

A. Ekström

O. Elvstam

J. Gruber

J. Hosein

O. Kirk

A. Weibull Wärnberg

X. Xu

L. Mendão

O. Valdenmaier

J.F. Larsen

M. Gardizi

T.W. Elsing

L. Ramesh Kumar

B. Pepa

A. Abutidze

Format Sitasi

APA MLA BibTeX

Han, W.M., Neesgaard, B., Knappik, M., Cavassini, M., Abela, I.A., Timiryasova, A. et al. (2026). Cancer burden and risk factors among women with HIV: a multi-regional study from the D:A:D and RESPOND cohort collaborationsResearch in context. https://doi.org/10.1016/j.eclinm.2025.103739

@article{han2026, author = {Win Min Han and Bastian Neesgaard and Michael Knappik and Matthias Cavassini and Irene A. Abela and Alisa Timiryasova and Lauren Greenberg and Charlotte Martin and Cristina Mussini and Ferdinand Wit and Caroline Sabin and Antonella Castagna and Akaki Abutidze and Wafaa El-Sadr and Fabrice Bonnet and Mario Sarcletti and Christina Carlander and Anna Hachfeld and Nina Weis and Vani Vannappagari and Felipe P. Rogatto and Lital A. Young and Sean R. Hosein and Lene Ryom and Kathy Petoumenos and W. El-Sadr and G. Calvo and F. Bonnet and F. Dabis and O. Kirk and A. Mocroft and M. Law and A. d'Arminio Monforte and L. Morfeldt and C. Pradier and P. Reiss and R. Weber and S. De Wit and A. Lind-Thomsen and R. Salbøl Brandt and M. Hillebreght and S. Zaheri and F. Wit and A. Scherrer and F. Schöni-Affolter and M. Rickenbach and A. Tavelli and I. Fanti and O. Leleux and J. Mourali and F. Le Marec and E. Boerg and E. Thulin and A. Sundström and G. Bartsch and G. Thompsen and C. Necsoi and M. Delforge and E. Fontas and C. Caissotti and K. Dollet and S. Mateu and F. Torres and K. Petoumenos and A. Blance and R. Huang and R. Puhr and K. Grønborg Laut and D. Kristensen and C. Sabin and A. Phillips and D. Kamara and C. Smith and C. Hatleberg and L. Ryom and A. Lind-Thomsen and R. Brandt and D. Raben and C. Matthews and A. Bojesen and A. Grevsen and J. Lundgren and B. Powderly and N. Shortman and C. Moecklinghoff and G. Reilly and X. Franquet and O. Kirk and P. Reiss and C. Smit and M. Ross and C. Fux and P. Morlat and E. Fontas and D. Kamara and J. Lundgren and C. Hatleberg and R. Weber and P. Morlat and C. Pradier and P. Reiss and N. Friis-Møller and J. Kowalska and J. Lundgren and C. Hatleberg and M. Law and A. d'Arminio Monforte and F. Dabis and F. Bonnet and P. Reiss and D. Kamara and J. Bohlius and M. Bower and G. Fätkenheuer and A. Grulich and J. Lundgren and A. Sjøl and P. Meidahl and J. Iversen and F. Wit and M. van der Valk and M. Hillebregt and K. Petoumenos and M. Law and W. Min Han and R. Zangerle and H. Appoyer and J. Vera and A. Clarke and B. Broster and L. Barbour and D. Carney and L. Greenland and R. Coughlan and S. De Wit and M. Delforge and J. Begovac and J. Kowalska and C. Stephan and M. Bucht and N. Chkhartishvili and O. Chokoshvili and A. d'Arminio Monforte and A. Rodano and A. Tavelli and I. Fanti and C. Mussini and V. Borghi and M. Menozzi and A. Cervo and C. Pradier and E. Fontas and K. Dollet and C. Caissotti and J. Casabona and J. Miro and F. Burns and C. Smith and F. Lampe and C. Chaloner and A. Castagna and A. Lazzarin and R. Lolatto and A. Sönnerborg and C. Carlander and P. Nowal and J. Vesterbacka and D. Carrick and K. Stigsäter and L. Mattson and H. Günthard and K. Kusejko and J. Wasmuth and J. Rockstroh and J. Vehreschild and G. Fätkenheuer and M. Scherer and G. Sauer and N. Schulze and L. Ryom and R. Campo and H. Garges and J. Lundgren and F. Bognar and J. Rooney and V. Vannappagari and G. Wandeler and L. Young and N. Dedes and M. Dunbar and C. Necsoi and L. Peters and D. Raben and A. Volny-Anne and L. Greenberg and N. Jaschinski and A. Timiryasova and L. Bansi-Matharu and E. Tusch and W. Bannister and A. Roen and D. Byonanebye and O. Fursa and A. Pelchen-Matthews and J. Reekie and V. Svedhem-Johansson and K. Grabmeier-Pfistershammer and J. Hoy and M. Bloch and D. Braun and A. Calmy and G. Schüttfort and M. Youle and S. Zona and A. Antinori and N. Bolokadze and J. Llibre and C. Schwarze-Zander and J. Hutchinson and C. Duvivier and G. Dragovic and R. Radoi and C. Oprea and M. Vasylyev and R. Matulionyte and V. Mulabdic and G. Marchetti and E. Kuzovatova and N. Coppola and I. Aho and S. Martini and H. Bucher and A. Harxhi and T. Wæhre and A. Pharris and A. Vassilenko and J. Bogner and A. Maagaard and E. Jablonowska and D. Elbirt and G. Marrone and C. Leen and C. Wyen and L. Dahlerup Rasmussen and C. Hatleberg and M. Kundro and E. Dixon Williams and J. Gallant and C. Cohen and A. Marongiu and A. Ekström and O. Elvstam and J. Gruber and J. Hosein and O. Kirk and A. Weibull Wärnberg and X. Xu and L. Mendão and O. Valdenmaier and J.F. Larsen and M. Gardizi and T.W. Elsing and L. Ramesh Kumar and B. Pepa and A. Abutidze}, title = {Cancer burden and risk factors among women with HIV: a multi-regional study from the D:A:D and RESPOND cohort collaborationsResearch in context}, year = {2026}, journal = {DOAJ}, doi = {10.1016/j.eclinm.2025.103739}, url = {http://www.sciencedirect.com/science/article/pii/S2589537025006741}, }

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Informasi Jurnal

Tahun Terbit: 2026
Sumber Database: DOAJ
DOI: 10.1016/j.eclinm.2025.103739
Akses: Open Access ✓