Preparation of activated carbon from Cephalosporin Mycelia Residue and its adsorption performance for cephalosporin antibiotics

The activated carbon was prepared with the Cephalosporin Mycelia Residue (CMR) obtained from Wichita Pharmaceutical Co., Ltd., and the adsorption kinetics and thermodynamics of Cefoperazone Sodium and Sulbactam Sodium (CS & SS) onto the activated carbon derived from the CMR were investigated. The results of activated carbon characterization showed that the iodine value of the activated carbon derived from the CMR was 1044 mg·g−1, the SBET was 596 m2·g−1, electron microscope scanning showed that the surface of activated carbon was porous and heterogeneous. Four kinds of kinetic models and four kinds of thermodynamic models were used to fit the experimental data of adsorption kinetics and thermodynamics, respectively. In addition, the ΔG0, ΔH0 and ΔS0 was calculated and analysised. The results showed that pseudo-second order model fitted the best to the adsorption kinetic data, indicating that the adsorption rate was proportional to the square of the adsorption site. Redlich-Peterson and Langmuir isotherm model fitted the best to the adsorption thermodynamic data, indicating that CS & SS was mainly adsorbed in single molecular layer on the surface of activated carbon. ΔH0> 0 indicated that the adsorption was endothermic, high temperature was conductive to the adsorption of CS & SS.