DOAJ Open Access 2025

New approach methodologies to assess wanted and unwanted drugs-induced immunostimulation

Valeria Bettinsoli Gloria Melzi Irene Marchese Sofia Pantaleoni Francesca Carlotta Passoni +1 lainnya

Abstrak

This review examines various classes of drugs, focusing on their therapeutic and adverse effects, particularly in relation to immunostimulation. We emphasize the potential of new approach methodologies (NAMs) to study both expected and unexpected immunostimulatory effects. By evaluating the modes of action of different immunostimulatory drugs, we aim to provide insights into effectively assessing unwanted immunostimulatory responses. The review begins by exploring drugs that stimulate the immune system—including immunostimulants, monoclonal antibodies, chemotherapeutics, and nucleic acid-based drugs—to outline NAMs that could be employed to evaluate immunostimulation.

Topik & Kata Kunci

Toxicology. Poisons

Penulis (6)

Valeria Bettinsoli

Gloria Melzi

Irene Marchese

Sofia Pantaleoni

Francesca Carlotta Passoni

Emanuela Corsini

Format Sitasi

APA MLA BibTeX

Bettinsoli, V., Melzi, G., Marchese, I., Pantaleoni, S., Passoni, F.C., Corsini, E. (2025). New approach methodologies to assess wanted and unwanted drugs-induced immunostimulation. https://doi.org/10.1016/j.crtox.2025.100222

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1016/j.crtox.2025.100222
Akses: Open Access ✓