Global research status and hot-spots of Sirt1 in aging: a bibliometric analysis based from 2005 to 2024

Background: Aging is a complex physiological process, regulated by multiple intertwined mechanisms. In this process, Sirt1 played a vital role with evidences increasing continually. Given the rapid expansion of research in this area, a comprehensive overview of the intellectual landscape is needed to guide future investigations. Based on, we conducted a bibliometric analysis of the relevant literature and visualized the results. Our study aimed to consolidate the current knowledge and provide insights into evolving research trends, thereby contributing to a deeper understanding of Sirt1's roles in aging process. Methods: On August 14th, 2024, we retrieved 2434 issues in Web of Science Core Collection (searching period from 2005 to 2024). Using VOSviewer, Citespace and bibliometrix, we analyzed these records in terms of annual publications/citations, spatiotemporal distribution, collaborations between regions/institutions/authors, co-references, and keywords. Result: We identified a stable development trend of researching on Sirt1 and aging. In the last 2 decades, the average growth rate of publication numbers was 34.52%, while in recent 5 years it fell to 10.8%. So far, China and the United States were more conductive and influential in this field. Their publications accounted for 39.56% and 26.17%, respectively. Of interests, since Hungary's publication numbers just accounted for 7% of the publications worldly, it had the strongest average citations. Besides, some institutions and countries had varieties of publications, but weak link strength, meaning further collaborations of them were needed in future study. Importantly, keywords analysis indicated that oxidative stress and calorie restriction were the main hot-spots of this field. Besides, inflammation, DNA damage, metabolism, mitochondrial dysfunction and autophagy might be new research directions in Sirt1 and aging. Conclusions: Above all, this study provided further insights into recent advances and future progression in researches on Sirt1 and aging.