DOAJ Open Access 2014

Chemical constituents and biological investigations of the aerial parts of Egyptian Clerodendrum inerme

Sabrin R.M. Ibrahim Khalid Z. Alshali Mostafa A. Fouad Ehab S. Elkhayat Rwaida A. Al Haidari +1 lainnya

Abstrak

B-friedoolean-5-ene-3-β-ol (1), β-sitosterol (2), stigmasta-5,22,25-trien-3-β-ol (3), betulinic acid (4), and 5-hydroxy-6,7,4′-trimethoxyflavone (5) were isolated from the aerial parts of Clerodendrum inerme L. (Verbenaceae). Their structures were established based on analyses of physical and spectroscopic data. Compounds 1, 4, and 5 were isolated for the first time from the plant. C. inerme L. was known as a rich source of terpenes, sterols, and phenolic compounds, so the antioxidant and anti-inflammatory activities were evaluated. The total methanolic extract (TME) and compound 5 showed scavenging activity with maximum inhibition of 61.84% for TME (100 μg/mL) and 37.19% for 5 (20 μM), respectively, using DPPH assay. In addition, the TME exhibited anti-inflammatory activity more than indomethacin at dose 200 mg/kg using the formalin induced hind paw edema method.

Topik & Kata Kunci

Therapeutics. Pharmacology Pharmacy and materia medica Pharmaceutical industry

Penulis (6)

Sabrin R.M. Ibrahim

Khalid Z. Alshali

Mostafa A. Fouad

Ehab S. Elkhayat

Rwaida A. Al Haidari

Gamal A. Mohamed

Format Sitasi

APA MLA BibTeX

Ibrahim, S.R., Alshali, K.Z., Fouad, M.A., Elkhayat, E.S., Haidari, R.A.A., Mohamed, G.A. (2014). Chemical constituents and biological investigations of the aerial parts of Egyptian Clerodendrum inerme. https://doi.org/10.1016/j.bfopcu.2014.05.002

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Informasi Jurnal

Tahun Terbit: 2014
Sumber Database: DOAJ
DOI: 10.1016/j.bfopcu.2014.05.002
Akses: Open Access ✓