DOAJ Open Access 2026

The interaction between the skin microbiome and antimicrobial peptides within the epidermal immune microenvironment: Bridging insights into atopic dermatitis

Shan Wang Ge Peng Alafate Abudouwanli Mengyao Yang Quan Sun +7 lainnya

Abstrak

The epidermal immune microenvironment is a multifaceted system in which the interplay between the skin microbiome and antimicrobial peptides plays a pivotal role in sustaining skin homeostasis and preventing dysbiosis. Disruption of these interactions can lead to inflammatory skin conditions such as atopic dermatitis. This review aims to explore the complex mechanisms by which antimicrobial peptides and the skin microbiome communicate within the epidermal immune microenvironment, emphasizing causal dynamics and the dual role of antimicrobial peptides. This analysis opens new avenues for targeted interventions, including antimicrobial peptide modulation and microbiome-based therapies, to restore skin health and mitigate inflammatory skin disorders.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (12)

Shan Wang

Ge Peng

Alafate Abudouwanli

Mengyao Yang

Quan Sun

Wanchen Zhao

Arisa Ikeda

Yi Tan

Lin Ma

Hideoki Ogawa

Ko Okumura

François Niyonsaba

Format Sitasi

APA MLA BibTeX

Wang, S., Peng, G., Abudouwanli, A., Yang, M., Sun, Q., Zhao, W. et al. (2026). The interaction between the skin microbiome and antimicrobial peptides within the epidermal immune microenvironment: Bridging insights into atopic dermatitis. https://doi.org/10.1016/j.alit.2025.08.002

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Informasi Jurnal

Tahun Terbit: 2026
Sumber Database: DOAJ
DOI: 10.1016/j.alit.2025.08.002
Akses: Open Access ✓