Asia-Pacific consensus statement on medication-related osteonecrosis of the jaw in patients with osteoporosisKey Points & RecommendationsKey Points & RecommendationsKey Points & RecommendationsKey Points & RecommendationsKey pointsKey PointsKey PointsKey Points & RecommendationsKey Points & RecommendationsKey Points & RecommendationsKey Points & RecommendationsKey PointsKey Points & Recommendations
Abstrak
A unified consensus statement on medication-related osteonecrosis of the jaw (MRONJ) has not yet been established among the Asian member countries or regions of the Asian Federation of Osteoporosis Societies (AFOS). This study aimed to develop a consensus on MRONJ in patients with osteoporosis across these countries and regions. In this study, the term “Asia-Pacific” refers specifically to the Asian member countries and regions of AFOS. A structured survey consisting of nine MRONJ-related questions was distributed across 10 countries and regions to assess the level of agreement and summarize regional perspectives. In addition, a manual literature review and voting were conducted to evaluate the current evidence on MRONJ. The key aspects of MRONJ, including definition, staging, diagnosis, pathogenesis, risk factors, management, and prevention, were generally consistent among the AFOS countries and regions. The annual incidence and incidence rate of MRONJ associated with low-dose antiresorptive therapy in patients with osteoporosis ranged from 0.025% to 0.136% and 21 to 283 cases per 100,000 person-years, respectively. However, evidence regarding the benefits of drug discontinuation before dental surgery, such as tooth extraction, remains insufficient. Large-scale, multinational studies across AFOS countries and regions are warranted to determine the incidence of MRONJ better and evaluate the impact of antiresorptive drug discontinuation before dental procedures. These findings may contribute to the development of effective evidence-based strategies for preventing MRONJ in patients with osteoporosis.
Topik & Kata Kunci
Penulis (32)
Akira Taguchi
Daisuke Inoue
Jin-Woo Kim
Keskanya Subbalekha
Wai Sin Chan
Hee Dong Chae
Chung-Hwan Chen
Ching-Lung Cheung
Eddie Siu Lun Chow
Yoon-Sok Chung
Linsey Gani
Muhammad Kamil bin Hassan
Unnop Jaisamrarn
Chakorn Vorakulpipat
Nutchada Sriyaranya
Aasis Unnanuntana
Tanawat Amphansap
Seng Bin Ang
Fen Lee Hew
Julie Li-Yu
Terence Ong Ing Wei
Jeyakantha Ratnasingam
Mark Anthony Sandoval
Thawee Songpatanasilp
Monica Therese Cating-Cabral
Thanut Valleenukul
Lalita Wattanachanya
Chih-Hsing Wu
Weibo Xia
Jawl-Shan Hwang
Hiroshi Hagino
Natthinee Charatcharoenwitthaya
Format Sitasi
Akses Cepat
- Tahun Terbit
- 2026
- Sumber Database
- DOAJ
- DOI
- 10.1016/j.afos.2026.02.001
- Akses
- Open Access ✓