DOAJ Open Access 2026

Antioxidant and neuroprotective effects of Launaea taraxacifolia extract against aluminum-induced neurotoxicity

Idorenyin U. Umoren Nnanake-Abasi O. Offiong Niibari W. Vite

Abstrak

This study evaluated the antioxidant and neuroprotective effects of ethanol leaf extract and fractions of Launaea taraxacifolia against aluminum chloride-induced neurotoxicity in rats. Sixty-six female Wistar rats were divided into eleven groups, receiving either control treatment, aluminum chloride, donepezil, or different doses/fractions of the plant extract for 21 days. Aluminum chloride significantly reduced antioxidant enzyme activities (SOD, CAT, GPx) and increased lipid peroxidation (MDA). Co-treatment with the ethanol extract, dichloromethane, ethylacetate, and n-butanol fractions restored antioxidant defenses and reduced MDA levels, whereas the n-hexane and aqueous fractions showed little effect. These findings indicate that Launaea taraxacifolia contains bioactive compounds with protective effects against oxidative stress and neuronal injury, supporting its potential as a natural neuroprotective agent.

Topik & Kata Kunci

Toxicology. Poisons Biotechnology Biology (General)

Penulis (3)

Idorenyin U. Umoren

Nnanake-Abasi O. Offiong

Niibari W. Vite

Format Sitasi

APA MLA BibTeX

Umoren, I.U., Offiong, N.O., Vite, N.W. (2026). Antioxidant and neuroprotective effects of Launaea taraxacifolia extract against aluminum-induced neurotoxicity. https://doi.org/10.1016/j.abst.2025.12.010

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Informasi Jurnal

Tahun Terbit: 2026
Sumber Database: DOAJ
DOI: 10.1016/j.abst.2025.12.010
Akses: Open Access ✓