DOAJ Open Access 2016

Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer

Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu +12 lainnya

Abstrak

ABSTRACT Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3′UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.

Topik & Kata Kunci

Cytology Animal biochemistry

Penulis (17)

Haiyang Zhang

Jingjing Duan

Yanjun Qu

Ting Deng

Rui Liu

Le Zhang

Ming Bai

Jialu Li

Tao Ning

Shaohua Ge

Xia Wang

Zhenzhen Wang

Qian Fan

Hongli Li

Guoguang Ying

Dingzhi Huang

Yi Ba

Format Sitasi

APA MLA BibTeX

Zhang, H., Duan, J., Qu, Y., Deng, T., Liu, R., Zhang, L. et al. (2016). Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer. https://doi.org/10.1007/s13238-015-0234-5

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Informasi Jurnal

Tahun Terbit: 2016
Sumber Database: DOAJ
DOI: 10.1007/s13238-015-0234-5
Akses: Open Access ✓