DOAJ Open Access 2023

CRISPR/Cas9 for hepatitis B virus infection treatment

Bo Cai Shixue Chang Yuhan Tian Shuai Zhen

Abstrak

Abstract Hepatitis B virus (HBV) infection remains a global health challenge. Despite the availability of effective preventive vaccines, millions of people are at risk of cirrhosis and hepatocellular carcinoma. Current drug therapies inhibit viral replication, slow the progression of liver fibrosis and reduce infectivity, but they rarely remove the covalently sealed circular DNA (cccDNA) of the virus that causes HBV persistence. Alternative treatment strategies, including those based on CRISPR/cas9 knockout virus gene, can effectively inhibit HBV replication, so it has a good prospect. During chronic infection, some virus gene knockouts based on CRISPR/cas9 may even lead to cccDNA inactivation. This paper reviews the progress of different HBV CRISPR/cas9, vectors for delivering to the liver, and the current situation of preclinical and clinical research.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (4)

Bo Cai

Shixue Chang

Yuhan Tian

Shuai Zhen

Format Sitasi

APA MLA BibTeX

Cai, B., Chang, S., Tian, Y., Zhen, S. (2023). CRISPR/Cas9 for hepatitis B virus infection treatment. https://doi.org/10.1002/iid3.866

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.1002/iid3.866
Akses: Open Access ✓