Immune‐monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium
Abstrak
Abstract Advancements in comprehending myelodysplastic neoplasms (MDS) have unfolded significantly in recent years, elucidating a myriad of cellular and molecular underpinnings integral to disease progression. While molecular inclusions into prognostic models have substantively advanced risk stratification, recent revelations have emphasized the pivotal role of immune dysregulation within the bone marrow milieu during MDS evolution. Nonetheless, immunotherapy for MDS has not experienced breakthroughs seen in other malignancies, partly attributable to the absence of an immune classification that could stratify patients toward optimally targeted immunotherapeutic approaches. A pivotal obstacle to establishing “immune classes” among MDS patients is the absence of validated accepted immune panels suitable for routine application in clinical laboratories. In response, we formed International Integrative Innovative Immunology for MDS (i4MDS), a consortium of multidisciplinary experts, and created the following recommendations for standardized methodologies to monitor immune responses in MDS. A central goal of i4MDS is the development of an immune score that could be incorporated into current clinical risk stratification models. This position paper first consolidates current knowledge on MDS immunology. Subsequently, in collaboration with clinical and laboratory specialists, we introduce flow cytometry panels and cytokine assays, meticulously devised for clinical laboratories, aiming to monitor the immune status of MDS patients, evaluating both immune fitness and identifying potential immune “risk factors.” By amalgamating this immunological characterization data and molecular data, we aim to enhance patient stratification, identify predictive markers for treatment responsiveness, and accelerate the development of systems immunology tools and innovative immunotherapies.
Topik & Kata Kunci
Penulis (58)
Cristina A. Tentori
Lin P. Zhao
Benedetta Tinterri
Kathryn E. Strange
Katharina Zoldan
Konstantinos Dimopoulos
Xingmin Feng
Elena Riva
Benjamin Lim
Yannick Simoni
Vidhya Murthy
Madeline J. Hayes
Antonella Poloni
Eric Padron
Bruno A. Cardoso
Michael Cross
Susann Winter
Aida Santaolalla
Bhavisha A. Patel
Emma M. Groarke
Daniel H. Wiseman
Katy Jones
Lauren Jamieson
Charles Manogaran
Naval Daver
Laura Gallur
Wendy Ingram
P. Brent Ferrell
Katja Sockel
Nicolas Dulphy
Nicolas Chapuis
Anne S. Kubasch
Astrid M. Olsnes
Austin Kulasekararaj
Hugues De Lavellade
Wolfgang Kern
Mieke Van Hemelrijck
Dominique Bonnet
Theresia M. Westers
Sylvie Freeman
Uta Oelschlaegel
David Valcarcel
Marco G. Raddi
Kirsten Grønbæk
Michaela Fontenay
Sanam Loghavi
Valeria Santini
Antonio M. Almeida
Jonathan M. Irish
David A. Sallman
Neal S. Young
Arjan A. van deLoosdrecht
Lionel Adès
Matteo G. Della Porta
Catherine Cargo
Uwe Platzbecker
Shahram Kordasti
i4MDS consortium
Akses Cepat
- Tahun Terbit
- 2024
- Sumber Database
- DOAJ
- DOI
- 10.1002/hem3.64
- Akses
- Open Access ✓